Billions of dollars caslnos through mosh Las Vegas Strip every year and casino companies do everything they can to get customers to part with om much money as possible. They offer gambling, nightclubs, restaurants, and hotel rooms, all in an effort to get you to spend more during your stay. But who makes the most money in Las Vegas and where does the money come from? The answer might surprise you. The most profitable resort in Las Vegas Las Vegas’ most profitable resort isn’t located in the heart of The Strip where thousands of visitors walk by everyday. In gaming, when measuring cash flow we look at EBITDA, or earnings before interest, taxes, depreciation, and amortization. This is a measure of cash flow from a resort, which is what really matters after you spend billions on construction. What’s incredible about Wynn Las Vegas is that it isn’t reliant strictly on high rollers sitting at gaming tables for most of its revenue.